Adjunctive Glucocorticoid Therapy in Patients with Septic Shock

Adjunctive Glucocorticoid Therapy in Patients with Septic Shock | NEJM:

BACKGROUND

Whether hydrocortisone reduces mortality among patients with septic shock is unclear.

METHODS

We randomly assigned patients with septic shock who were undergoing mechanical ventilation to receive hydrocortisone (at a dose of 200 mg per day) or placebo for 7 days or until death or discharge from the intensive care unit (ICU), whichever came first. The primary outcome was death from any cause at 90 days.